For years metformin has been associated with anti-aging and anti-cancer benefits. It was recently approved for clinical trials in the study of aging.
Metformin, also known as the glucose eater (Glucophage) was first discovered in 1922. It was first approved and brought to market in 1958-59 in Britain. It was later approved in Canada in 1972. The US Food and Drug Administration joined in the approval process around 1995. It was a long time coming, but so far evidence points that this may be one of the few pharmaceutical synthetic non bio-identical treatments to take seriously.
Metformin and Anti-Aging
Here are some notable Metformin facts:
2012 – Metformin declared first drug of choice for type 2 diabetes by US and European diabetes experts.
2013 – World Health Organization Declares it an Essential Oral Anti-diabetic Medicine.
UK Prospective Diabetes Study finds reduced risk of myocardial infarction and overall mortality.
Recent data shows anti-aging benefits [Mahmood K, Naeem M, Rahimnajjad NA. Metformin: the hidden chronicles of a magic drug. Eur J Intern Med 2013;24:20–6.].
Long-term use has shown to be safe for preventing and delaying type 2 diabetes [Diabetes Prevention Program Research Group. Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study. Diabetes.
Since 1990, more than 1,000 studies have been published confirming data regarding metformin’s anti-aging properties, including weight-loss, glucose control and cardiovascular disease defense.
One study consisting of 8,000 diabetics followed over 10 years showed a 54% lower incidence of all cancers compared to the general population. [ Libby G, Donnelly LA, Donnan PT, Alessi DR, Morris AD, Evans JM. New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care. 2009 Sep;32(9):1620-5.].
Metformin Anti-Aging and Anti-Cancer Benefits
To date, there have been no long-term human studies regarding the appropriate dose of Metformin that delivers the optimal result for anti-aging purposes. However, if we look at the major studies conducted thus far on diabetics, one can assume it safe to follow a typical dose used for type 2 or pre-diabetics.
A typical starting dosage for type 2 diabetics is 500mg of Metformin twice per day, according to the physicians desk reference. The physician will likely keep the dose at that level until follow up. This is a very safe starting dose of Metformin. On the follow up exam, the following blood tests may be used to measure Metformin’s effectiveness on the individual patient:
AIC – Measures average glucose in blood for last 90 days below 5-6%
Fasting Insulin – Measures the effectiveness of Metformin to lower fasting insulin levels below 5 micro IU/ML
CBC Blood Panel – this test looks at cholesterol, glucose, triglycerides, kidney and liver function
To learn more up to date Metformin information go to: .
Your physician will determine which test or combination of tests should be reviewed to best assess you dosage.
Note that these therapies and protocols are not proven nor have they been evaluated by the FDA and they remain controversial. Always seek the advice of your physician before considering if this type of therapy is something you should consider for yourself.
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